Publications

Link to NCBI Bibliography

  1. Baldassano SN, Brinkmann BH, Ung H, Blevins T, Conrad EC, Leyde K, Cook MJ, Khambhati AN, Wagenaar JB, Worrell GA, Litt B. Crowdsourcing seizure detection: algorithm development and validation on human implanted device recordings. Brain. 2017 Apr 27. doi: 10.1093/brain/awx098.  [Epub ahead of print]
    PubMed
  2. Hill CE, Thomas B, Sansalone K, Davis KA, Shea JA, Litt B, Dahodwala N. Improved availability and quality of care with epilepsy nurse practitioners. Neurol Clin Pract. 2017 Apr;7(2):109-117. doi: 10.1212/CPJ.0000000000000337. PMCID: PMC5386842.
    PubMed
  3. Kiar G, Gorgolewski KJ, Kleissas D, Roncal WG, Litt B, Wandell B, Poldrack RA, Wiener M, Vogelstein RJ, Burns R, Vogelstein JT. Science in the cloud (SIC): A use case in MRI connectomics. Gigascience. 2017 May 1;6(5):1-10. doi: 10.1093/gigascience/gix013.

    PubMed

  4. Khambhati AN, Bassett DS, Oommen BS, Chen SH, Lucas TH, Davis KA, Litt B. Recurring Functional Interactions Predict Network Architecture of Interictal and Ictal States in Neocortical Epilepsy. eNeuro. 2017 Mar 8;4(1). pii: ENEURO.0091-16.2017. doi: 10.1523/ENEURO.0091-16.2017. eCollection 2017 Jan-Feb. PMCID: PMC5343278.
    PubMed
  5. Ung H, Davis KA, Wulsin D, Wagenaar J, Fox E, McDonnell JJ, Patterson N, Vite CH, Worrell G, Litt B. Temporal behavior of seizures and interictal bursts in prolonged intracranial recordings from epileptic canines. Epilepsia. 2016 Dec;57(12):1949-1957. doi: 10.1111/epi.13591. PubMed PMID: 27807850. PMCID: PMC5241889.
    PubMed
  6. Wiener M, Sommer FT, Ives ZG, Poldrack RA, Litt B. Enabling an Open Data Ecosystem for the Neurosciences. Neuron. 2016 Nov 23;92(4):929. doi: 10.1016/j.neuron.2016.11.009. PubMed PMID: 27883904.
    PubMed
  7. Wiener M, Sommer FT, Ives ZG, Poldrack RA, Litt B. Enabling an Open Data Ecosystem for the Neurosciences. Neuron. 2016 Nov 2;92(3):617-621. doi: 10.1016/j.neuron.2016.10.037. PubMed PMID: 27810004.
    PubMed
  8. Hudgins E, Brown MG, Litt B, Davis K, Richardson AG, Lucas T. Focal      Seizures Induced by Intracranial Electroencephalogram Grids. Cureus. 2016 Oct 15;8(10):e831. PMCID: PMC5111965.
    PubMed
  9. Khambhati AN, Davis KA, Lucas TH, Litt B, Bassett DS.Neuron.Virtual Cortical Resection Reveals Push-Pull Network Control Preceding Seizure Evolution. 2016 Aug 23. pii: S0896-6273(16)30424-X. doi: 10.1016/j.neuron.2016.07.039. [Epub ahead of print] PMCID: PMC5017915.
    PubMed
  10. Kini LG, Gee JC, Litt B. Computational analysis in epilepsy neuroimaging: A survey of features and methods. Neuroimage Clin. 2016 Feb 23;11:515-29. doi: 10.1016/j.nicl.2016.02.013. eCollection 2016. Review. PMCID: PMC4833048.
    PubMed
  11. Baldassano S, Wulsin D, Ung H, Blevins T, Brown MG, Fox E, Litt B. A novel seizure detection algorithm informed by hidden Markov model event states. J Neural Eng. 2016 Jun;13(3):036011. Epub 2016 Apr 21. PMCID: PMC4888894.
    PubMed
  12. Yu KJ, Kuzum D, Hwang SW, Kim BH, Juul H, Kim NH, Won SM, Chiang K, Trumpis M, Richardson AG, Cheng H, Fang H, Thompson M, Bink H, Talos D, Seo KJ, Lee HN, Kang SK, Kim JH, Lee JY, Huang Y, Jensen FE, Dichter MA, Lucas TH, Viventi J, Litt B, Rogers JA. Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex. Nat Mater.2016 July; 15(7): 782–791. Epub 2016 Apr 18. PMCID: PMC4919903.
    PubMed
  13. Brinkmann BH, Wagenaar J, Abbot D, Adkins P, Bosshard SC, Chen M, Tieng QM, He J, Muñoz-Almaraz FJ, Botella-Rocamora P, Pardo J, Zamora-Martinez F, Hills M, Wu W, Korshunova I, Cukierski W, Vite C, Patterson EE, Litt B, Worrell GA. Crowdsourcing reproducible seizure forecasting in human and canine epilepsy. Brain. 2016 Jun;139(Pt 6):1713-22.Epub 2016 Mar 31. PMCID: PMC 5022671.
    PubMed
  14. Vanleer AC, Blanco JA, Wagenaar JB, Viventi J, Contreras D, Litt B. Millimeter-scale epileptiform spike propagation patterns and their relationship to seizures. J Neural Eng. 2016 Apr;13(2):026015. Epub 2016 Feb 9. PMCID: PMC4807853.
    PubMed
  15. Dynamic Network Drivers of Seizure Generation, Propagation and Termination in Human Neocortical Epilepsy. Khambhati AN, Davis KA, Oommen BS, Chen SH, Lucas TH, Litt B, Bassett DS. PLoS Comput Biol. 2015 Dec 17;11(12):e1004608. doi: 10.1371/journal.pcbi.1004608. eCollection 2015 Dec. PMCID:PMC4682976.
    PubMed
  16. Davis KA, Ung H, Wulsin D, Wagenaar J, Fox E, Patterson N, Vite C, Worrell G, Litt B. Mining continuous intracranial EEG in focal canine epilepsy: Relating interictal bursts to seizure onsets. Epilepsia. 2016 Jan;57(1):89-98. doi: 10.1111/epi.13249. Epub 2015 Nov 26. PMCID: PMC4770560.
    PubMed
  17. Davis KA, Nanga RP, Das S, Chen SH, Hadar PN, Pollard JR, Lucas TH, Shinohara RT, Litt B, Hariharan H, Elliott MA, Detre JA, Reddy R. Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy. Sci Transl Med. 2015 Oct 14;7(309):309ra161. PMCID: PMC4710355.
    PubMed
  18. Chen HI, Bohman LE, Emery L, Martinez-Lage M, Richardson AG, Davis KA, Pollard JR, Litt B, Gausas RE, Lucas TH. Lateral Transorbital Endoscopic Access to the Hippocampus, Amygdala, and Entorhinal Cortex: Initial Clinical Experience. ORL J Otorhinolaryngol Relat Spec. 2015 Sep 30;77(6):321-332. [Epub ahead of print]
    PubMed
  19. Brinkmann BH, Patterson EE, Vite C, Vasoli VM, Crepeau D, Stead M, Howbert JJ, Cherkassky V, Wagenaar JB, Litt B, Worrell GA. Forecasting Seizures Using Intracranial EEG Measures and SVM in Naturally Occurring Canine Epilepsy: PLoS One. 2015 Aug 4;10(8):e0133900. PMCID: PMC4524640.
    PubMed
    Brinkmann BH, Patterson EE, Vite C, Vasoli VM, Crepeau D, Stead M, Howbert JJ, Cherkassky V, Wagenaar JB, Litt B, Worrell GA. Forecasting Seizures Using Intracranial EEG Measures and SVM in Naturally Occurring Canine Epilepsy: Corection: Forecasting Seizures Using Intracranial EEG Measures and SVM in Naturally Occurring Canine Epilepsy: PLoS One. 2016 May 26;11(5):e0156476. PMCID: PMC4881954.
    PubMed
  20. Wagenaar JB, Worrell GA, Ives Z, Matthias D, Litt B, Schulze-Bonhage A. Collaborating and Sharing Data in Epilepsy Research: J Clin Neurophysiol. 2015 Jun;32(3):235-9. PMCID: PMC4455031.
    PubMed
  21. Litt, Brian. Engineering the Next Generation of Brain Scientists. Neuron. 2015 Apr 8;86(1):16-20. doi: 10.1016/j.neuron.2015.03.029.
    PubMed
  22. Chen W, Liu X, Litt B. Logistic-weighted regression improves decoding of finger flexion from electrocorticographic signals. Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:2629-32. doi: 10.1109/EMBC.2014.6944162.
    PubMed
  23. Azarion AA, Wu J, Davis KA, Pearce A, Krish VT, Wagenaar J, Chen W, Zheng Y, Wang H, Lucas TH, Litt B, Gee JC. An open-source automated platform for three-dimensional visualization of subdural electrodes using CT-MRI coregistration. Epilepsia. 2014 Dec;55(12):2028-37. doi: 10.1111/epi.12827. Epub 2014 Nov 6. PMCID: PMC4285663.
    PubMed
  24. Kuzum D, Takano H, Shim E, Reed JC, Juul H, Richardson AG, de Vries J, Bink H, Dichter M, Lucas TH, Coulter DA, Cubukcu E, Litt B. Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging. Nature Communications. 20 October 2014;5:5259. doi:10.1038/ncomms6259. PMCID: PMC4331185.
    PubMed
  25. Wulsin DF, Fox EB, Litt B. Modeling the Complex Dynamics and Changing Correlations of Epileptic Events. Artif Intell. 2014 Nov 1;216:55-75. PMCID: PMC4180222.
    PubMed
  26. Geller AS, Burke JF, Sperling MR, Sharan AD, Litt B, Baltuch GH, Lucas TH 2nd, Kahana MJ. Eye closure causes widespread low-frequency power increase and focal gamma attenuation in the human electrocorticogram. Clin Neurophysiol. 2014 Sep;125(9):1764-73. doi: 10.1016/j.clinph.2014.01.021. Epub 2014 Feb 10. PMCID: PMC4127381.
    PubMed
  27. Escabi MA, Read HL, Viventi J, Kim DH, Higgins NC, Storace D, Liu AS, Gifford AM, Burke JF, Campisi M, Kim YS, Avrin AE, Van der Spiegel J, Huang Y, Li M, Wu J, Rogers JA, Litt B, Cohen YE. A high-density, high-channel count, multiplexed µECoG array for auditory-cortex recordings. J Neurophysiol. 2014 Sep 15;112(6):1566-83. doi: 10.1152/jn.00179.2013. Epub 2014 Jun 11. PMCID: PMC4137255.
    PubMed
  28. Denison T, Litt B. Advancing neuromodulation through control systems: a general framework and case study in posture-responsive stimulation. Neuromodulation. 2014 Jun;17 Suppl 1:48-57. doi: 10.1111/ner.12170.
    PubMed
  29. Howbert JJ, Patterson EE, Stead SM, Brinkmann B, Vasoli V, Crepeau D, Vite CH, Sturges B, Ruedebusch V, Mavoori J, Leyde K, Sheffield WD, Litt B, Worrell GA. Forecasting seizures in dogs with naturally occurring epilepsy. PLoS One. 2014;9(1):e81920. doi: 10.1371/journal.pone.0081920. PMCID: PMC3885383.
    PubMed
  30. Ritaccio A, Brunner P, Crone NE, Gunduz A, Hirsch LJ, Kanwisher N, Litt B, Miller K, Moran D, Parvizi J, Ramsey N, Richner TJ, Tandon N, Williams J, Schalk G. Proceedings of the Fourth International Workshop on Advances in Electrocorticography. Epilepsy Behav. 2013 Nov;29(2):259-68. PMCID: PMC3896917.
    PubMed
  31. Coles LD, Patterson EE, Sheffield WD, Mavoori J, Higgins J, Michael B, Leyde K, Cloyd JC, Litt B, Vite C, Worrell GA. Feasibility study of a caregiver seizure alert system in canine epilepsy. Epilepsy Res. 2013 Oct;106(3):456-60. doi:pii: S0920-1211(13)00171-X. 10.1016/j.eplepsyres.2013.06.007. Epub 2013 Aug 18. PMCID:PMC3903427.
    PubMed
  32. Rodriguez Merzagora A, Coffey TJ, Sperling MR, Sharan A, Litt B, Baltuch G, Jacobs J. Repeated stimuli elicit diminished high-gamma electrocorticographic responses. Neuroimage. 2014 Jan 15;85 Pt 2:844-52. doi:pii: S1053-8119(13)00758-1. 10.1016/j.neuroimage.2013.07.006. Epub 2013 Jul 16. PMCID:PMC3859728.
    PubMed
  33. Pearce A, Wulsin D, Blanco JA, Krieger A, Litt B, Stacey WC. Temporal Changes of Neocortical High Frequency Oscillations in Epilepsy. J Neurophysiol. 2013 Sep;110(5):1167-79. doi: 10.1152/jn.01009.2012. Epub 2013 Jun 12. PMCID:PMC3763087.
    PubMed
  34. Famm K, Litt B, Tracey KJ, Boyden ES, Slaoui M. Drug Discovery: a jump-start for electroceuticals. Nature. 2013 April;496(7444): 159-61. PMCID: PMC4179459.
    PubMed
  35. van Gerven Marcel AJ, Maris Eric, Sperling Michael, Sharan Ashwini, Litt Brian, Anderson Christopher, Baltuch Gordon, Jacobs Joshua. Decoding the memorization of individual stimuli with direct human brain recordings. NeuroImage. 2013 Jan;70C: 223-232. PMCID: PMC3580011. 
    PubMed
  36. Ritaccio A, Beauchamp M, Bosman C, Brunner P, Chang E, Crone N, Gunduz A, Gupta D, Knight R, Leuthardt E, Litt B, Moran D, Ojemann J, Parvizi J, Ramsey N, Rieger J, Viventi J, Voytek B, Williams J, Schalk G. Proceedings of the Third International Workshop on Advances in Electrocorticography. Epilepsy Behav. 2012 Dec;25(4):605-13. doi: 10.1016/j.yebeh.2012.09.016. PMCID: PMC4041796.
    PubMed
  37. Smart Otis, Maus Douglas, Marsh Eric, Dlugos Dennis, Litt Brian, Meador Kimford: Mapping and mining interictal pathological gamma (30-100 Hz) oscillations with clinical intracranial EEG in patients with epilepsy. Expert systems with applications. 2012 Jun;39(8): 7355-7370. PMCID: PMC3480232.
    PubMed
  38. Morton NW, Kahana MJ, Rosenberg EA, Baltuch GH, Litt B, Sharan AD, Sperling MR, Polyn SM. Category-Specific Neural Oscillations Predict Recall Organization During Memory Search. 2013 Oct;23(10):2407-22. PMCID: PMC3767960.
    PubMed
  39. Ritaccio A, Boatman-Reich D, Brunner P, Cervenka MC, Cole AJ, Crone N, Duckrow R, Korzeniewska A, Litt B, Miller KJ, Moran DW, Parvizi J,Viventi J, Williams J, Schalk G. Proceedings of the second international workshop on advances in electrocorticography.Epilepsy Behav. 2011 Dec;22(4):641-50.
    PubMed
  40. Viventi J, Kim D-H, Vigeland L, Frechette E, Blanco J, Kim Y-S, Avrin A, Tiruvadi V, Hwang S-W, Chamberlain A, Wulsin D, Davis K, Gelber C, Palmer L, Van der Spiegel J, Wu J, Xiao J, Huang Y, Contreras D, Rogers JA, Litt B: Flexible, Foldable, Actively Multiplexed, High-Density Electrode Array for Mapping Brain Activity in vivo. Nature Neuroscience. 2011 Nov 13;14(12):1599-605. PMCID: PMC3235709.
    PubMed
  41. Blanco JA, Stead M, Krieger A, Stacey W, Maus D, Marsh E, Viventi J, Lee KH, Marsh R, Litt B, Worrell GA: Data mining neocortical high-frequency oscillations in epilepsy and controls. Brain. 2011 October;134(Pt 10): 2948-59. PMCID: PMC3187540.
    PubMed
  42. Davis KA, Sturges BK, Vite CH, Ruedebusch V, Worrell G, Gardner AB, Leyde K, Sheffield WD, Litt B: A novel implanted device to wirelessly record and analyze continuous intracranial canine EEG. Epilepsy Res. 2011 Sep;96(1-2): 116-22. PMCID: PMC3175300.
    PubMed
  43. Manning JR, Polyn SM, Baltuch GH, Litt B, Kahana MJ: Oscillatory patterns in temporal lobe reveal context reinstatement during memory search. Proc Natl Acad Sci U S A. 2011 Aug. 108(31): 12893-7. PMCID: PMC3150951.
    PubMed
  44. Wulsin DF, Gupta JR, Mani R, Blanco JA, Litt B. Modeling electroencephalography waveforms with semi-supervised deep belief nets: fast classification and anomaly measurement. J Neural Eng. 2011 Jun;8(3):036015. PMCID: PMC3193936.
    PubMed
  45. Kim DH, Lu N, Ghaffari R, Kim YS, Lee SP, Xu L, Wu J, Kim RH, Song J, Liu Z, Viventi J, de Graff B, Elolampi B, Mansour M, Slepian MJ, Hwang S, Moss JD, Won SM, Huang Y, Litt B, Rogers JA. Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy. Nat Mater. 2011 Apr;10(4):316-23. PMCID: PMC3132573.
    PubMed
  46. Stacey WC, Krieger A, Litt B. Network recruitment to coherent oscillations in a hippocampal computer model. J Neurophysiol. 2011 Apr;105(4):1464-81. PMCID: PMC3075292.
    PubMed
  47. H. Bink, Y. Lai, S.R. Saudari, B. Helfer, J. Viventi, J. Van der Spiegel, B. Litt, Kagan, C. Flexible organic electronics for use in neural sensing. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:5400-3. PMCID: PMC4787299.
    PubMed
  48. Chamberlain AC, Viventi J, Blanco JA, Kim D-H, Rogers JA, Litt B. Millimeter-Scale Epileptiform Spike Patterns and Their Relationship to Seizures. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:761-4. PMCID: PMC4807854.
    PubMed
  49. Gupta JR, Marsh ED, Nieh HA, Porter BE, Litt B. Discrete gamma oscillations identify the seizure onset zone in some pediatric epilepsy patients. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:3095-8.
    PubMed
  50. Blanco JA, Stead M, Krieger A, Viventi J, Marsh WR, Lee KH, Worrell G, Litt B. Unsupervised Classification of High-Frequency Oscillations in Human Neocortical Epilepsy and Control Patients. J Neurophysiol. 2010 Nov;104(5):2900-12. PMCID:PMC2997042.
    PubMed
  51. Stead S, Bower M, Brinkmann B, Lee K, Marsh R, Myer F, Litt B, VanGompel J, Worrell, G. Microseizures and the Spatiotemporal Scales of Human Partial Epilepsy. Brain. 2010;133(9):2789-97. PMC: PMCID2929333
    PubMed
  52. Kim DH, Viventi J, Amsden J, Xiao J, Vigeland L, Kim Y-S, Blanco J, Frechette E, Contreras D, Kaplan D, Omenetto F, Huang Y, Hwang K-C, Zakin M, Litt B, Rogers JA. Dissolvable Films of Silk Fibroin for Ultrathin, Conformal Bio-Integrated Electronics. Nat Mater. 2010 Jun;9(6):511-7. PMCID: PMC3034223.
    PubMed
  53. Jacobs J, Korolev IO, Caplan JB, Ekstrom AD, Litt B, Baltuch G, Fried I, Schulze-Bonhage A, Madsen JR, Kahana MJ. Right-lateralized Brain Oscillations in Human Spatial Navigation. J Cogn Neurosci. 2010; 22(5):824-36. PMCID: PMC2839416.
    PubMed
  54. Marsh ED, Peltzer B, Brown Iii MW, Wusthoff C, Storm Jr PB, Litt B, Porter, BE. Interictal EEG spikes identify the region of electrographic seizure onset in some, but not all, pediatric epilepsy patients. Epilepsia. 2010; 51(4): 592-601. PMCID: PMC2907216.
    PubMed
  55. Viventi J, Kim DH, Moss J, Kim Y-S, Blanco J, Anetta N, Hicks A, Xiao J, Huang Y, Callans DJ, Rogers JA, Litt B. A Conformal, Bio-interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology. Sci. Transl. Med. 2010; 2(24): 24ra22. PMCID: PMC3039774.
    PubMed
  56. van Vugt MK, Schulze-Bonhage A, Litt B, Brandt A, Kahana MJ. Hippocampal Gamma Oscillations Increase with Memory Load. J Neurosci. 2010;30(7):2694-9. PMCID: PMC2835496
    PubMed
  57. Viventi J, Blanco J, Litt B. Mining terabytes of submillimeter-resolution ECoG datasets for neurophysiologic
    biomarkers. Conf Proc IEEE Eng Med Biol Soc. 2010;1:3825-6. PMCID: PMC3132566.
    PubMed
  58. van Vugt MK, Schulze-Bonhage A, Sekuler R, Litt B, Brandt A, Baltuch G, Kahana, MJ. Intracranial electroencephalography reveals two distinct similarity effects during item recognition. Brain Res. 2009;1299:33-44. PMCID: PMC2763991.
    PubMed
  59. Stacey WC, Lazarewicz MT, Litt B. Synaptic noise and physiological coupling generate high-frequency oscillations in a hippocampal computational model. J Neurophysiol. 2009;102(4):2342-57. PMCID: PMC2775383.
    PubMed
  60. Qin L, Guo W, Litt B. A Time-Frequency Functional Model for Locally Stationary Time Series Data. Journal of Computational and Graphical Statistics. 2009;18(3):675-693. PMCID: PMC2836603.
    PubMed
  61. Kelley MS, Jacobs MP, Lowenstein DH, NINDS Epilepsy Benchmark Stewards. The NINDS epilepsy research benchmarks. Epilepsia. 2009; 50(3): 579-82. PMCID: PMC2874963.
    PubMed
  62. Snyder DE, Echauz J, Grimes DB, Litt B. The statistics of a practical seizure warning system. J Neural Eng. 2008;5(4):392-401. PMCID: PMC2888045.
    PubMed
  63. Worrell GA, Gardner AB, Stead SM, Hu S, Goerss S, Cascino GJ, Meyer F B, Marsh R, Litt B. High-frequency oscillations in human temporal lobe: simultaneous microwire and clinical macroelectrode recordings. Brain. 2008;131(4):928-37. PMCID: PMC2760070.
    PubMed
  64. Stacey WC, Litt B. Technology insight: neuroengineering and epilepsy- designing devices for seizure control. Nat Clin Pract Neurol. 2008;4(4):190-201. PMCID: PMC 2904395.
    PubMed
  65. Wiggins M, Saad A, Litt B, Vachtsevanos G. Evolving a Bayesian classifier for ECG-based age classification in medical applications, in Journal of Applied Soft Computing. 2008; 8(1):599-608. PMCID: PMC3193938.
    PubMed
  66. Halpern CH, Samadani U, Litt B, Jaggi JL, Baltuch GH. Deep brain stimulation for epilepsy. Neurotherapeutics. 2008;5(1):59-67. PMCID: PMC2941772.
    PubMed
  67. Sederberg PB, Schulze-Bonhage A, Madsen JR, Bromfield EB, Litt B, Brandt A, Kahana MJ. Gamma oscillations distinguish true from false memories. Psychol Sci. 2007;18(11):927-32. PMCID: PMC2897900
    PubMed
  68. Firpi H, Smart O, Worrell G, Marsh E, Dlugos D, Litt B. High-frequency oscillations detected in epileptic networks using swarmed neural-network features. Ann Biomed Eng. 2007;35(9):1573-84.
    PubMed
  69. Gardner AB, Worrell GA, Marsh E, Dlugos D, Litt B. Human and automated detection of high-frequency oscillations in clinical intracranial EEG recordings. Clin Neurophysiol. 2007;118(5):1134-43. PMCID: PMC2020804.
    PubMed
  70. Wong S, Gardner AB, Krieger AM, Litt B. A stochastic framework for evaluating seizure prediction algorithms using hidden Markov models. J Neurophysiol. 2007;97(3):2525-32. PMCID: PMC2230664.
    PubMed
  71. Litt B, Krieger A. Of seizure prediction, statistics, and dogs: a cautionary tail. Neurology. 2007;68(4):250-1.
    PubMed
  72. Dube C, Richichi C, Bender RA, Chung G, Litt B, Baram TZ. Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain. 2006;129(4):911-22. PMCID: PMC3100674
    PubMed
  73. Gardner AB, Krieger A, Vachtsevanos G, Litt B. One-Class Novelty Detection for Seizure Analysis from Intracranial EEG. Journal of Machine Learning Research. 2006;7:1025-44.
    Gardner 2006.pdf
  74. Esteller R, Echauz J, D'Alessandro M, Worrell G, Cranstoun S, Vachtsevanos G, Litt, B. Continuous energy variation during the seizure cycle: towards an on-line accumulated energy. Clin Neurophysiol. 2005;116(3):517-26. PMCID: PMC2941767
    PubMed
  75. D'Alessandro M, Vachtsevanos G, Esteller R, Echauz J, Cranstoun S, Worrell G, Parish L, Litt B. A multi-feature and multi-channel univariate selection process for seizure prediction. Clin Neurophysiol. 2005;116(3):506-16.
    PubMed
  76. Lehnertz K, Litt B. The First International Collaborative Workshop on Seizure Prediction: summary and data description. Clin Neurophysiol. 2005;116(3):493-505.
    PubMed, Lehnertz 2005.pdf
  77. Stead M, Worrell GA, Litt B. Frequency and Dependence of Long Range Temporal Correlations in Human Hippocampal Energy Fluctuations. Complexity, 2005;10(5):35-44.
    http://onlinelibrary.wiley.com/doi/10.1002/cplx.20088/pdf
  78. Worrell GA, Parish L, Cranstoun SD, Jonas R, Baltuch G, Litt B. High-frequency oscillations and seizure generation in neocortical epilepsy. Brain. 2004;127(Pt 7):1496-506.
    PubMed
  79. Kerrigan JF, Litt B, Fisher RS, Cranstoun S, French JA, Blum DE, Dichter M, Shetter A, Baltuch G, Jaggi J, Krone S, Brodie M, Rise M, Graves N. Electrical stimulation of the anterior nucleus of the thalamus for the treatment of intractable epilepsy. Epilepsia. 2004;45(4):346-54.
    PubMed
  80. Parish LM, Worrell GA, Cranstoun SD, Stead SM, Pennell P, Litt B. Long-range temporal correlations in epileptogenic and non-epileptogenic human hippocampus. Neuroscience. 2004;125(4):1069-76.
    PubMed http://www.sciencedirect.com/science/article/pii/S0306452204001599
  81. D'Alessandro M, Esteller R, Vachtsevanos G, Hinson A, Echauz J, Litt B. Epileptic seizure prediction using hybrid feature selection over multiple intracranial EEG electrode contacts: a report of four patients. IEEE Trans Biomed Eng. 2003;50(5):603-15.
    PubMed, D'Alessandro 2003.pdf
  82. Niederhauser JJ, Esteller R, Echauz J, Vachtsevanos G, Litt B. Detection of seizure precursors from depth-EEG using a sign periodogram transform. IEEE Trans Biomed Eng. 2003;50(4):449-58.
    PubMed, Niederhauser 2003.pdf
  83. Witte H, Iasemedis L, Litt B, Guest Editors. Editorial. Special Issue on Epileptic Seizure Prediction. Special Issue of IEEE Transactions on Biomedical Engineering. 2003;50(5):537-9.
    Witte 2003.pdf
  84. Litt B. Evaluating devices for treating epilepsy. Epilepsia. 2003;44 Suppl 7:30-7.
    PubMed
  85. Worrell GA, Cranstoun SD, Echauz J, Litt B. Evidence for self-organized criticality in human epileptic hippocampus. Neuroreport. 2002;13(16):2017-21.
    PubMed
  86. Cranstoun SD, Ombao HC, von Sachs R, Guo W, Litt B. Time-frequency spectral estimation of multichannel EEG using the Auto-SLEX method. IEEE Trans Biomed Eng. 2002;49(9):988-96.
    PubMed, Cranstoun 2002.pdf
  87. Litt B, Echauz J. Prediction of epileptic seizures. Lancet Neurol. 2002;1(1)22-30.
    PubMed, http://www.sciencedirect.com/science/article/pii/S1474442202000030
  88. Litt B, Lehnertz K. Seizure prediction and the preseizure period. Curr Opin Neurol. 2002;15(2):173-7.
    PubMed
  89. Valmadrid C, Voorhees C, Litt B, Schneyer CR. Practice patterns of neurologists regarding bone and mineral effects of antiepileptic drug therapy. Arch Neurol. 2001;58(9):1369-74.
    PubMed
  90. Litt B, Esteller R, Echauz J, D'Alessandro M, Shor R, Henry T, Pennell P, Epstein C, Bakay R, Dichter M, Vachtsevanos G. Epileptic seizures may begin hours in advance of clinical onset: a report of five patients. Neuron. 2001;30(1):51-64.
    PubMed http://www.sciencedirect.com/science/article/pii/S0896627301002628

    McKeown M, McNamara J. When do epileptic seizures really begin? Accompanying editorial. Neuron. 2001;30(1):1-3.
    PubMed
  91. Esteller R, Vachtsevanos G, Echauz J, Litt B. A Comparison of Waveform Fractal Dimension Algorithms. IEEE Transactions on Circuits & Systems. 2001;48(2):177-83.
    Esteller 2001.pdf
  92. Litt B, Baltuch G. Brain Stimulation for Epilepsy. Epilepsy & Behavior. 2001;2:S61-S67. http://www.sciencedirect.com/science/article/pii/S1525505001902082
  93. Epstein CM, Woodard JL, Stringer AY, Bakay RA, Henry TR, Pennell PB, Litt B. Repetitive transcranial magnetic stimulation does not replicate the Wada test. Neurology. 2000;55(7):1025-7.
    PubMed
  94. Silverman IE, Berman, DM, Dike GL, Sung GY, Litt B, Wityk RJ. Vertebrobasilar dolichoectasia associated with Marfan syndrome. J Stroke Cerebrovasc Dis. 2000;9:196-8.
  95. Litt B, Wityk RJ, Hertz SH, Mullen PD, Weiss H, Ryan DD, Henry TR. Nonconvulsive status epilepticus in the critically ill elderly. Epilepsia. 1998;39(11):1194-202.
    PubMed, http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1157.1998.tb01311.x/abstract
  96. Wityk RJ, Lehman D, Klag M, Coresh J, Ahn H, Litt B. Race and sex differences in the distribution of cerebral atherosclerosis. Stroke. 1996;27(11):1974-80.
    PubMed
  97. Webber WR, Litt B, Wilson K, Lesser RP. Practical detection of epileptiform discharges (EDs) in the EEG using an artificial neural network: a comparison of raw and parameterized EEG data. Electroencephalogr Clin Neurophysiol. 1994;91(3):194-204.
    PubMed
  98. Webber WR, Litt B, Lesser RP, Fisher RS, Bankman I. Automatic EEG spike detection: what should the computer imitate? Electroencephalogr Clin Neurophysiol. 1993;87(6):364-73.
    PubMed
  99. Litt B. Dipoles and the EEG. American Journal of EEG Technology. 1991;31:119-21.
  100. Hansen B, Ko HW, Fisher, RS, Litt B. Practical Limits on the Biomagnetic Inverse Process Determined From In Vitro Measurements in Spherical Conducting Volumes. Physics in Medicine and Biology. 1988;33(1):105-11.
    PubMed,hansen 1988.pdf (with permission of IOP Publishing Ltd)

Recent Conference Papers

  1. Ives Z, Yan Z, Zheng N, Litt B, Wagenaar J. Looking at Everything in Context. Conference paper, 7th Biennial Conference on Innovative Data Systems Research (CDIR 2015).
  2. Wulsin D, Fox E, Litt B. Parsing Epileptic Events Using a Markov Switching Process for Correlated Time Series. International Conference on Machine Learning (ICML), 2013 June.
  3. Wulsin D, Jensen S, Litt B. A Hierarchical Dirichlet Process Model with Multiple Levels of Clustering for Human EEG Seizure Modeling. Proceedings of the 29th International Conference on Machine Learning, Edinborough, Scotland, UK (2012).
  4. Wulsin D, Litt B. An unsupervised method for identifying regions that initiate seizures on intracranial EEG.
    Conf Proc IEEE Eng Med Biol Soc. 2011;2011:3091-4.
    PubMed

Book

Wilbourn A, Litt B, Isley M, Krauss G, Shields R, Levin K, Electroencephalography and Evoked Potentials. Electromyography/ Electroencephalography Vol. VII: SpaceLabs Medical;1994.

Editorials, Reviews, Book Chapters

 

 

  1. Fisher RS, Litt B., Stacey WC. Deep Brain Stimulation for Epilepsy. In: Winn RH, editor. Youman’s Neurological Surgery. 2011; In press.
  2. Maus D, Litt B. Modern Electrocorticography. In: Baltuch G, Villemure JG, editors. Operative Techniques in Epilepsy Surgery: Thieme; 2009.
  3. Echauz J, Wong S, Litt B. Seizure Analysis and Detection In Vivo. In: Baraban S, editor. Animal Models of Epilepsy: Methods and Innovations; Series: Neuromethods: Humana Press Inc.; 2009.
  4. Krieger D, Litt B. Seizure Prediction: Its Evolution and Therapeutic Potential. In: Shorvon SD, Pedley T, editors. Blue Book of Neurology: the epilepsies 3. Philadelphia: Saunders; 2008.
  5. Echauz J, Wong S, Smart O, Gardner A, Worrell G, Litt B. Quantitative methods for tracking seizure generation in epileptic networks. In: Soltesz I, Staley K, editors. Computational Neuroscience in Epilepsy: Elsevier; 2008.
  6. Lehnertz K, Le Van Quyen M, Litt B. Seizure Prediction: A Comprehensive Review. In: Pedley T, Engel J Jr, editors. Epilepsy, A Comprehensive Textbook. 2nd ed. Philadelphia: Lippincott, Williams & Wilkins; 2008.
  7. Litt B, Cranstoun S. EEG Engineering Principles. In: Pedley, Ebersole, editors. Current Practice of Clinical Electroencephalography. N.Y.: Raven Press; 2003.
  8. Litt B, Cranstoun S. Recording from Anterior Nucleus of the Thalamus. In: Luders H, editor. Brain Stimulation for Epilepsy. London: Martin-Dunitz; 2003.
  9. Kolb S, Litt B. Epilepsy in the Intensive Care Unit and Emergency Room. In: Devinsky O, Ettinger A, editors. Managing Epilepsy and Co-Existing Disorders: Butterworth – Heinemann; 2002. p. 515-34.
  10. Glosser G, Litt B. Non-epileptic Seizures. In: Johnson R, Griffin J, McArthur J, editors. Current Therapy in Neurology. Philadelphia: B.C. Decker; 2001. p. 58-60.
  11. Burgess R, Bej M, Brenner R, Gotman J, Jacobs E, Kelm G, et al. Technological Requirements for Long-Term Monitoring. In: Luders H, Comair Y, editors. Epilepsy Surgery. 2nd ed. NY: Lippincott, Williams & Wilkins; 2000.
  12. Litt B, Krauss GL. Pharmacologic Approach to the Acute Seizure Patient. In: Chernow B, editor. Pharmacologic Approach to the Critically Ill Patient. 2nd ed. 1993. p. 484-506.
  13. Litt B, Fisher R. EEG Engineering Principles. In: Daly, Pedly, editors. Current Practice of Clinical Electroencephalography. Second Edition ed. N.Y.: Raven Press; 1990.

Granted Patents

  1. Blanco J, Litt B, inventors. Method For Automatic, Unsupervised Classification Of High-Frequency Oscillations In Physiological Recordings. US 2016.
    patent9326698
  2. Rogers J, Kim D, Omenetto F, Kaplan D, Litt B, et al, inventors. Implantable Biomedical Devices on Bioresorbable Substrates. China 2010800668164. 2016.
  3. Rogers J, Kim D, Litt B, Viventi J, inventors. Flexible and Scalable Sensor Arrays for Recording and Modulating Physiologic Activity. European Patent Office 2265171. 2016.
  4. Kagan C, Litt B, Viventi J, inventors. Self-Adaptive Bio-Signal and Modulation Device. US 2015.
    patent9072887
  5. Litt B, Viventi J, inventors. Flexible and Scalable Sensor Arrays for Recording and Modulating Physiologic Activity. US 2015.
    patent9107592
  6. Rogers J, Kim D, Omenetto F, Kaplan D, Litt B, et al, inventors. Implantable Biomedical Devices on Bioresorbable Substrates. France 2547258. 2015.
  7. Rogers J, Kim D, Omenetto F, Kaplan D, Litt B, et al, inventors. Implantable Biomedical Devices on Bioresorbable Substrates. EPO 2547258. 2015.
  8. Rogers J, Kim D, Omenetto F, Kaplan D, Litt B, et al, inventors. Implantable Biomedical Devices on Bioresorbable Substrates. Germany 2547258. 2015.
  9. Rogers J, Kim D, Omenetto F, Kaplan D, Litt B, et al, inventors. Implantable Biomedical Devices on Bioresorbable Substrates. JP 2013-500037. 2015.
  10. Rogers J, Kim D, Omenetto F, Kaplan D, Litt B, et al, inventors. Implantable Biomedical Devices on Bioresorbable Substrates. United Kingdom 2547258. 2015.
  11. Rogers J, Kim D-H, Litt B, Viventi J, Inventors; Flexible and Scalable Sensor Arrays for Recording and Modulating Physiologic Activity. US 2015.
    patent8934965
  12. Litt B, Viventi J, Inventors; Flexible and Scalable Sensor Arrays for Recording and Modulating Physiologic Activity. JP Patent Number 5535950, 2014.
  13. Rogers J, Kim D-H, Omenetto F, Kaplan DL, Litt B, Viventi J, Huang Y, Amsden J, inventors; Implantable Biomedical Devices on Bioresorbable Substrates. US 2014.
    patent8666471
  14. Echauz J, Worrell G, Litt Brian, inventors; Active Control of Epileptic Seizures and Diagnosis Based On Critical Systems-like Behavior. U.S. 2012.
    patent8150522
  15. Echauz J, Litt Brian, Esteller R, Vachtsevanos G, inventors; Unified Probabilistic Framework for Predicting and Detecting Seizure Onsets in the Brain and MultiTherapeutic Device. U.S. 2011.
    patent8086294
  16. Echauz J, Litt Brian, Esteller R, Vachtsevanos G, inventors; Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control. U.S.2011.
    patent8065011
  17. Echauz J, Esteller R, Litt B, Vachtsevanos G, inventors; Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device. U.S. 2008.
    patent7333851
  18. Esteller R, Echauz J, Litt B, Vachtsevanos G, inventors; Adaptive Method and Apparatus for Forecasting and Controlling Neurological Disturbances Under a Multi-Level Control. U.S. 2006.
    patent7146218

  19. Echauz J, Esteller R, Litt B, Vachtsevanos G, inventors; Unified Probabilistic Framework for Predicting and Detecting Seizure Onsets in the Brain and Multitherapeutic Device. U.S. 2004.
    patent6678548
  20. Litt B, Vachtsevanos G, Echauz J, Esteller R, inventors; Method and Apparatus for Predicting the Onset of Seizures Based on Features Derived From Signals Indicative of Brain Activity. U.S. 2003.
    patent6658287
  21. Esteller R, Echauz J, Litt B, Vachtsevanos G, inventors; Adaptive Method and Apparatus for Forecasting and Controlling Neurological Disturbances Under a Multi-Level Control. U.S. 2003.
    patent6594524

Patent Applications in Process

University of Pennsylvania: Flexible and Scalable Sensor Arrays for Recording and Modulating Physiologic Activity (National Phase filed 3/12/2009). EP Patent Number 09721084.3, 2009.

University of Pennsylvania: System for Biological Sensing and Stimulating Applications Using High-Density Array Device (National Phase filed). HK Patent Number 13104913.1, 2010.

University of Pennsylvania: System for Biological Sensing and Stimulating Applications Using High-Density Array Device (National Phase filed). JP Patent Number 2012-544735, 2010.

University of Pennsylvania: System for Biological Sensing and Stimulating Applications Using High-Density Array Device (National Phase filed). EP Patent Number 10842518.2, 2010.

University of Pennsylvania, University of Illinois: High-Speed, High Resolution Electrophysiology In-Vivo Using Conformal Electronics (application filed 12/16/2010). Taiwan Patent Number 099144263, 2010.

University of Pennsylvania, University of Illinois: High-Speed, High Resolution Electrophysiology In-Vivo Using Conformal Electronics (application filed 12/15/2010). US Patent Number 12/968,637, 2010.

University of Pennsylvania, University of Illinois: Implantable Biomedical Devices on Bioresorbable Substrates (National Phase filed 9/28/2010). KR Patent Number 10-2012-7027062, 2010.

University of Pennsylvania, University of Illinois: Implantable Biomedical Devices on Bioresorbable Substrates (application filed). TW Patent Number 100108419, 2010.

University of Pennsylvania; University of Illinois: Implantable Biomedical Devices on Bioresorbable Substrates (Divisional filed 9/28/2010). CN, 2010.

University of Pennsylvania; University of Illinois: Implantable Biomedical Devices on Bioresorbable Substrates (National Phase filed 9/28/2010). IN Patent Number 8151/DELNP/2012, 2010.

University of Pennsylvania; University of Illinois: Implantable Biomedical Devices on Bioresorbable Substrates (National Phase filed). CN Patent Number 2010800668164, 2010.

University of Pennsylvania; University of Illinois: Implantable Biomedical Devices on Bioresorbable Substrates (National Phase filed). JP Patent Number 2013-500037, 2010.

University of Pennsylvania; University of Illinois: Implantable Biomedical Devices on Bioresorbable Substrates (National Phase filed). EP Patent Number 10848120.1, 2010.

University of Pennsylvania, University of Illinois: Implantable Biomedical Devices on Bioresorbable Substrates (application filed 9/28/2010). USA Patent Number 12/892,001, 2010.

University of Pennsylvania: Method For Automatic, Unsupervised Classification Of High-Frequency Oscillations In Physiological Recordings (Utility filed). US Patent Number 13/385,413, 2012.

University of Pennsylvania: Self-Adaptive Bio-Signal Sensing and Modulation Device (National Phase filed). USA Patent Number 13/321,339, 2012.

University of Pennsylvania; University of Illinois: Conformable Actively Multiplexed High-Density Surface Electrode Array For Brain Interfacing (Utility filed). EP Patent Number 12792485.0, 2012.

University of Pennsylvania; University of Illinois: Conformable Actively Multiplexed High-Density Surface Electrode Array For Brain Interfacing (Utility filed). USA Patent Number 13/486,726, 2012.

University of Pennsylvania; University of Illinois: Implantable Biomedical Devices on Bioresorbable Substrates (continuation filed). US Patent Number 14/140,299, 2013.

University of Pennsylvania; University of Illinois: Implantable Biomedical Devices on Bioresorbable Substrates (filed). HK Patent Number 13107825.1, 2013.

University of Pennsylvania: Methods, System and Computer Readable Media For Real Time Spatiotemporal Visualization of Neurophysiologic Biomarkers. USA Patent Number PCT/US2014/039865, 2014.

University of Pennsylvania: Graphene-Passivated Implantable Electrodes (Provisional filed). USA Patent Number 61/924,315, 2014.

University of Pennsylvania: Transparent Electrode Arrays for Visualization, Simultaneous Imaging and Electrophysiology (Provisional filed). US Patent Number 61/974,651, 2014.